The 7 Best Bromelain Supplement 2022(Reviews & Buyer’s Guide)

Often, the solution to our afflictions is found hidden in plants in the form of vitamins, minerals, and other substances. Accordingly, bromelain is one of several plant-based natural remedies with multiple supposed benefits.

Bromelain is a proteolytic enzyme sourced from pineapple juice and stem, used in treating and relieving various health conditions. The enzyme is purported to effectively treat or reduce pain, swellings, blood clots, sores, kidney stones, burns, and other health issues. However, most mainstream medical practitioners contend that the use of bromelain in the medical field lacks sufficient scientific evidence and research.

So far, bromelain has undergone a series of folk medicine and research measures for its potential effectiveness against certain medical conditions. Still, it’s only earned one clinical approval by the European Medicines Agency as NexoBrid since 2012. Its authorized clinical use involves removing scar tissues in severe skin burns.

Although bromelain hasn’t been approved by the Food and Drug Administration (FDA), its sale and use as a dietary supplement are allowed in the US. There are various brands and dosage forms available for purchase and use. Hence, we’ve formulated a comprehensive review of the best bromelain supplement brands, including their dosage forms, benefits, and potential side effects.

This article also includes a buyer’s guide enabling you to make an informed decision when choosing a bromelain supplement for use. After reading this review and buyer’s guide article, you’d be able to discern an ideal bromelain supplement brand, its required dosage, available dosage form, benefits, and what you may expect after its intake.

The Top 3 Bromelain Supplements

Before properly analyzing the top brands, let’s briefly run through the world’s three leading bromelain supplement brands. They include:

1. Top-Selling Organic Bromelain Supplement — NOW®  Quercetin with Bromelain

Amazon’s number 1 bestselling bromelain nutritional supplement; supports the immune system, thousands of excellent customers’ reviews and ratings; non-GMO; gluten-free; vegan; GMP-certified.

2. The Best Organic Bromelain Supplement for Allergy — ForestLeaf Quercetin Bromelain

Advanced allergy supplement; contains Vitamin C and stinging nettle; considerable positive customers reviews and ratings; non-GMO; gluten-free; vegan

3. The Best Bromelain Supplement for Inflammation — Herbal Secrets® Bromelain

Anti-inflammatory properties; proteolytic enzyme; relatively affordable; GMP-certified; non-GMO; thousands of positive users reviews and ratings

A Brief Recap of the Properties and Biochemistry of Bromelain

Bromelain is a protein-digesting enzyme derived from the stem or fruit of pineapples (Ananas spp). Pineapples are the most common edible members of the family Bromeliaceae.

Depending on the part of the pineapple that produces it, there are two types of bromelain, viz stem and fruit bromelain. Stem and fruit bromelain have different enzymatic compositions. The term “bromelain” typically indicates stem bromelain.

Bromelain consists of the following components:

• Thiol endopeptidases
• Phosphatase
• Glucosidase
• Cellulase
• Peroxidase
• Eucharist
• Protease inhibitors

Several in vitro and in vivo surveys indicate that bromelain possesses fibrinolytic, antithrombotic, anti-edematous, and anti-inflammatory properties.

Hence, bromelain is thought to be beneficial in the treatment of various health conditions, including:

• Angina pectoris
• Bronchitis
• Surgical trauma
• Sinusitis
• Thrombophlebitis

Other purported therapeutic applications of bromelain include:

• Wound debridement
• Enhanced drug absorption
• Relief of osteoarthritis, diarrhea, and cardiovascular disorders.

One remarkable property of bromelain is its ability to be significantly absorbable yet retain its proteolytic activity.

Seven (7) Best Bromelain Supplement Brands

There are multiple organic bromelain supplement brands available for purchase. Yet, some brands outdo others on various reviews and rating platforms.

We’ve compiled a list of the seven (7) best bromelain supplements to enable you to purchase a suitable brand with high potency and fewer side effects.

We arrived at our conclusion based on the following:

• The brand’s success in a series of laboratory tests and clinical trials
• Compliance with FDA, non-GMO, and GMP guidelines
• The supplement’s potency
• Considerable customers and past users’ reviews and ratings
• Minimum possible side effects and non-toxicity
• The supplement’s ease of consumption
• Easy absorbance
• Adequate amounts of active substances
• Proper packaging and clear labeling

Although our words are reliable, you can learn more about a product by visiting the manufacturers’ websites and several trustworthy reviews platforms, including Yelp, Trustpilot, Reddit, and Quora.

That said, the seven best organic bromelain supplement brands include:

1. NOW® Quercetin With Bromelain: Top-Selling Organic Bromelain Supplement

Produced and packed in the US by NOW® Foods, this brand is ranked as Amazon’s #1 best-selling bromelain nutritional supplement. The product is intended for healthy immune system support. Each supplement serving packs 165 mg of 2400 GDU/g bromelain thought to enhance immune function.

The product also offers 800 mg of quercetin per serving, an antioxidant that boosts seasonal immune system function and facilitates normal respiratory function. Again, the manufacturers suggest the consumers take two capsules 20 minutes before a meal, twice per day. Subjects with sensitive stomachs are advised to consume the supplement with food.

NOW® Quercetin With Bromelain Veg Capsules is reportedly made under Good Manufacturing Practice (GMP) without genetically modified organisms (GMOs). The product is also supposedly vegan, Halal and Kosher-certified, soy-free, citrus-free, and gluten-free.

The brand is only suitable for adults.

Caution:

• The product is unsuitable for people with pineapple allergies.
• Quercetin may interact with other medications. Hence, individuals should consult a physician before proceeding to consume the product.
• Pregnant and nursing women and people with certain health conditions, especially kidney dysfunction, should consult a healthcare professional before using the product.
• Keep the product out of children’s reach.
• Store the product in a cool, dry place.
• The Food and Drug Administration (FDA) hasn’t evaluated the manufacturer’s statements.

2. ForestLeaf Quercetin Bromelain: The Best Organic Bromelain Supplement for Allergy

ForestLeaf Quercetin Bromelain is regarded as the best quercetin and bromelain supplement by many for treating allergies. The product also contains vitamin C (ascorbic acid) and stinging nettle leaf extract (Urtica dioica).

With 150 mg of 2400 GDU/g bromelain and supposed natural antihistamines, the brand is thought to be effective against seasonal allergies, sinus, and inflammation. It’s also believed to enhance immune function, respiratory health, and the cardiovascular system.

The manufacturers advise the subjects to take two capsules of the supplement daily or as directed by a physician, adding that you could also take it with food. They also claim that the product was produced in an FDA-approved facility under good manufacturing practice (GMP) and is gluten-free and vegan-friendly.

The product is suitable for adults.

Caution:

• Keep the product out of children’s reach.
• Pregnant and nursing women and individuals taking certain medications should consult a physician before using the supplement.
• Store the product in a cool, dry place.
• The Food and Drug Administration (FDA) hasn’t verified the manufacturer’s claims.

3. Herbal Secrets® Bromelain: The Best Bromelain Supplement for Inflammation

Herbal Secrets® Bromelain is among the leading bromelain nutritional supplements on Amazon, with thousands of excellent reviews and ratings. The product is a proteolytic enzyme that’s alleged to have anti-inflammatory properties helping to lessen pain, swelling, and joint stiffness. In tablet form, each supplement serving contains 500 mg of 300 GDU/g bromelain.

The brand is also reported to support protein digestion and stimulate nutrient absorption. When using the product as a dietary supplement, the manufacturers suggest the consumer takes one tablet thrice or four times daily with or in between meals or as directed by a physician.

Herbal Secrets® Bromelain is relatively affordable, costing less than $20 (less than $10 with discounts) as of March 2022.

Similarly, the product is said to be made under good manufacturing practice (GMP) without preservatives, artificial flavors, and colors and is non-vegan-friendly. Meanwhile, it’s not intended for people below 18 years.

Caution:

• The product isn’t suitable for individuals under 18 years of age and pregnant and nursing women.
• People taking certain medications and those with medical conditions should consult a doctor before using the drug.
• Quit using the supplement and consult a medical practitioner if you experience any adverse reactions

4. Horbaach® Bromelain

Manufactured and packed in the US by Horbaach®, this product is intended for use as a dietary supplement. It’s a potent pineapple enzyme that supports digestive and joint health. Each supplement serving contains an outstanding 1700 mg of bromelain from 600 gelatin digestive units (GDU) per gram, probably the highest on our list.

The product comprises 120 quick-release capsules of bromelain reportedly produced without GMOs under good manufacturing practice (GMP). It’s also free of gluten, soy, milk, lactose, and artificial colors. As of 2022, the brand is among the top five bestselling bromelain supplements on Amazon.

According to the manufacturers, adults are expected to take two (2) quick release capsules of the supplement with water shortly before a meal.

Caution:

• The Food and Drug Administration (FDA) hasn’t evaluated the manufacturer’s statements.
• Keep the product out of children’s reach.
• The supplement is unsuitable for people allergic to pineapples.

5. NOW® Bromelain 500 mg

Another product by NOW Foods®, this supplement is intended for proper gastrointestinal function support and muscles and joints relief.

The product is regarded as a natural proteolytic enzyme-containing 500 mg of 2400 GDU/g bromelain. While this formula sports a higher bromelain dose, it doesn’t contain quercetin like the other Now® Foods formula. Moreover, it’s considered Amazon’s choice bromelain nutritional supplement and has earned significant positive reviews from customers and its past users.

The manufacturers claim that the product is manufactured in a GMP-registered facility and isn’t manufactured with wheat, soy, gluten, milk, shellfish, and tree nut ingredients. They also suggest that adults take one capsule of the supplement 1–2 times daily, with or between meals.

Caution:

• The product is intended for adults only.
• Pregnant and nursing women and individuals taking certain medications (especially antiplatelet medications) should seek medical advice before using the supplement.
• The supplement isn’t suitable for people with a pineapple allergy.
• Keep the product out of children’s reach.
• The FDA hasn’t reviewed the manufacturer’s statements.
• The product isn’t intended to treat, cure, or diagnose any disease.

6. Amazing Formulas Quercetin Bromelain

Manufactured by Amazing Nutrition®, this dietary supplement is said to have antioxidant properties. The product is intended for free radical damage reduction and healthy inflammatory and immune response support. It’s also reported to enhance cardiovascular and respiratory health.

The supplement brand comprises 800 mg of quercetin (quercetin dihydrate) and 165 mg of bromelain (2400 GDU/g). According to the manufacturers, subjects (individuals at least 18 years old) should take two vegetable capsules of the dietary supplement twice to thrice daily, 20 minutes before a meal, or as directed by a medical professional.

Furthermore, the product is purportedly produced in a GMP-certified facility, is vegan-friendly, and lacks gluten, soy, and sodium.

Caution:

• The supplement isn’t intended for individuals under 18 years of age.
• Pregnant and nursing women, and individuals with certain medical conditions, including those taking medications, should seek professional advice from their healthcare provider before using the product.
• Keep the product out of children’s reach.
• Discontinue use and contact a healthcare practitioner if adverse reactions result from using the supplement.

7. Doctor’s Best® Quercetin Bromelain

Doctor’s Best® Quercetin Bromelain is a dietary supplement designed to support healthy immune function. The product contains 500 mg of quercetin derived from Dimorphondra mollis and 250 mg of bromelain (2400 GDU/g). As a dietary supplement, it’s thought to support circulatory, digestive, and joint health.

The manufacturers suggest that the brand is non-GMO, vegan, gluten-free, and soy-free. It’s recommended to take two capsules of Doctor’s Best bromelain supplement once daily or as directed by a nutrition-informed healthcare practitioner.

Caution:

• The supplement isn’t suitable for people taking digoxin.
• Store the product in a cool, dry place.

How to Choose the Best Bromelain Supplement: Buyer’s Guide

Stumbling upon a particular bromelain supplement is conceivable. However, the real problem lies in choosing the right brand.

When considering choosing a bromelain supplement, you have to evaluate the following factors:

• Your particular medical condition
• The supplement’s potential side effects
• The benefits and functions of the supplement
• The supplement brand’s dosage form
• Other substances in the supplement

Some Therapeutic Applications of Bromelain Supplements

Herbal medicine proponents use Bromelain supplements for specific medical conditions. Some bromelain supplement brands are more effective against a particular health condition than others. Hence, it’s crucial to choose a brand that best suits your health needs.

That said, here are the most prominent areas where bromelain formulas have found scientifically-proven use:

Effect of Bromelain Supplement on Inflammation

Some studies in humans and rats have shown that bromelain has anti-inflammatory properties, reducing chronic inflammation, cancer occurrence, and cancer progression. Bromelain works by downregulating cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE-2) in human monocytic leukemia cell lines and murine microglial cells.

COX-2 is an enzyme triggering cancer-related inflammation. On the other hand, PGE-2 is a lipid that promotes inflammation and tumor progression and suppresses immune function.

The best bromelain supplement for inflammation on this list is Herbal Secrets® Bromelain.

Effect of Bromelain Supplement on Wound Debridement

Clinically, bromelain is used in retracting scar tissues from injuries. One clinical study indicated that bromelain cleared all facial bruises and several hematomas from some injured boxers in four days. This may be because bromelain facilitates wound debridement by preventing blood platelets aggregations.

Similarly, bromelain has also shown fibrinolytic activity and thrombus inhibitory function. The substance is also effective in dissolving arteriosclerotic plague in experimental animals. The only approved clinical application of bromelain as of 2022—NexoBrid—is intended for removing scar tissues and treating severe skin burns.

In this light, Bromelux Natural Skin Recovery Formula by Bela Vi Therapeutics is one of Amazon’s best bromelain supplements for bruising.

Effect of Bromelain Supplement on Immune Function

Several analyses demonstrate the immunomodulatory effects of bromelain. The enzyme activates natural killer cells and enhances granulocyte-macrophage-colony stimulating factors and interleukins (IL-2, IL-6), supporting immune function.

Bromelain supplements also help defend the systems against various microbes. For example, the supplementation may protect animals against diarrhea-causing enterotoxins resulting from E.coli and Vibrio cholera infection.

For this function, bromelain prevents the adhesion of foreign bodies to the intestine by altering the receptors’ attachment sites and affects the intestinal secretory signaling pathways. It also works synergistically with antibiotics to offset certain infections.

Furthermore, bromelain displays antihelminthic function against gastrointestinal nematodes, including Trichuris muris, and antifungal actions against Candida albicans.

NOW®  Quercetin with Bromelain is thought to be effective for seasonal immune function support.

Effect of Bromelain Supplement on Symptomatic Vitreous Opacities and Eye Floaters

Aggregation and liquefaction of vitreous collagen fibrils may result in symptomatic vitreous capacities and intraocular hemorrhage. The cellular debris from these conditions can lead to ocular floaters (eye floaters).

According to one Taiwanese medical journal, a mixture of three proteolytic enzymes extracted from crude pineapple—bromelain, papain, and ficin—effectively cleared ocular floaters and opacities. Bromelain does this by cleaving and dissolving myofibrillar and collagen fibrils.

Although there’s currently no formula widely recognized as the best bromelain supplement for eye floaters, any bromelain supplement brand with papain and ficin would be a decent choice.

Effect of Bromelain Supplement on Cancer

Some surveys suggest that bromelain monitors the body’s normal cellular activities and regulates cellular growth and proliferation, thus preventing their transformation into cancer cells. The enzyme also deters DNA damage resulting from genomic instability and toxicity. Through G2/M arrest and melanoma cells and human epidermoid cells apoptosis, bromelain inhibits the nuclear factor translocation crucial for cancer development.

The metastatic spread of cancerous cells from the initial site is responsible for the high mortality rates linked to cancer. Bromelain remedies the condition by inhibiting cancer metastasis. Again, it uncoats cancer cells and exposes them to the immune system through its antiplatelet activities.

Bromelain supplement brands with elevated antioxidant properties supposedly help against cancer.

Pros and Cons of Bromelain Supplements

Bromelain supplement is reported to have several health benefits and a few potential side effects. This section examines the positive and adverse aspects of using bromelain supplements.

Benefits of Bromelain Supplements

The purported advantages of bromelain supplements include:

• Anti-inflammatory and antioxidant roles: Bromelain is thought to prevent various inflammations, including rheumatoid arthritis and sinusitis, and clear off free radicals from the body.
• Cancer and tumor therapies
• Immune function support and allergies prevention
• Cardiovascular and respiratory health enhancement
• Scar tissue retraction and wound debridement
• Relief of joint pain and muscle soreness
• Gastrointestinal health support
• Enhanced drug absorption

Side Effects of Bromelain Supplements

When choosing a bromelain supplement, it’s best to choose a brand with fewer possible side effects.

The potential side effects that may arise from using bromelain supplements include:

• Abnormal uterine bleeding
• Drowsiness
• Diarrhea
• Heavy period
• Increased heart rate
• Nausea
• Indigestion
• Vomiting

NOTE: Bromelain may trigger allergic reactions and asthmatic symptoms in people with pineapple allergies or asthma. These potential symptoms are breathing difficulties, throat tightness, hives, rashes, and itchy skin.

Available Dosage Forms of Bromelain Supplement

Bromelain supplements come in various dosage forms, including:

• Vegetable capsules
• Quick-release capsules
• Tablets
• Powder

It’s vital to purchase a bromelain supplement that it’s easier for you to consume. For example, people with nauseous conditions may find it easier to ingest capsules than tablets.

Best Bromelain Supplement: More FAQs

What’s the best bromelain supplement brand?

NOW® Quercetin with Bromelain holds the top spot among the top bromelain formulas highlighted in this review. Notably, apart from ranking as Amazon’s #1 top-selling formula, this supplement is highly certified and rated highly by users, as seen in customer reviews.

What’s the best amylase, bromelain, and lipase supplement?

Dr. Matthew #1 Digestive Enzymes is among the most remarkable bromelain supplement packed with amylase and lipase.

What’s the best quercetin and bromelain supplement?

We rank NOW® Quercetin with Bromelain as the best quercetin bromelain supplement on this list, containing 800 mg of quercetin and 165 mg of bromelain. However, if you want one that caters explicitly to allergies, the ForestLeaf Quercetin Bromelain is ideal.

What’s the best bromelain supplement on Reddit?

According to Reddit, NOW® Bromelain 500 mg is the best bromelain supplement.

What’s the best bromelain supplement in the UK?

HealthAid® Bromelain 500 mg is the most-rated bromelain supplement on Amazon UK.

What’s the best bromelain supplement for inflammation?

Herbal Secrets® Bromelain dietary supplement is recognized for its anti-inflammatory properties.

What’s the best bromelain supplement for bruising?

Bromelux Natural Skin Recovery Formula by Bela Vi Therapeutics is among the best bromelain supplements for bruising.

Where can I visit to buy bromelain near me?

If you’re seeking where to buy bromelain supplements, you can try several e-commerce platforms, such as Amazon and U-Buy.

What’s the best bromelain supplement for eye floaters?

Any bromelain supplement brand containing papain and ficin is thought to be suitable for eye floaters.

Final Thoughts

Pineapple is a nutritious fruit providing the proteolytic enzyme bromelain for use as a dietary supplement. Although the enzyme has passed some clinical tests and trials, its use hasn’t been generally accepted. Still, many individuals agree that bromelain supplements are effective in various health conditions.

Since there are various bromelain supplement brands on the market today, it’s best to choose a well-acclaimed one. In addition, you should consult a healthcare practitioner before using a bromelain supplement, especially if you’re managing medical conditions or using certain medications. Similarly, it’s critical to go through the precautions associated with a particular supplement brand.

Summarily, we hope our comprehensive reviews and buyer’s guide about the best bromelain supplement brands help you make an informed decision when buying a bromelain product.

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