As the best painkiller for sciatica will vary depending on the individual’s specific situation and level of pain. However, some common painkillers that may be effective for treating sciatica include over-the-counter options such as ibuprofen or acetaminophen, as well as prescription medications such as muscle relaxants, antidepressants, or corticosteroids.
In some cases, interventional treatments such as epidural steroid injections or nerve blocks may also be recommended. Ultimately, it is important to work with a healthcare provider to determine the best painkiller for sciatica based on the individual’s needs.
20 Best Pain Killer For Sciatica
Product Image | Product Name | Features | Price |
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NatraBio Sciatica Neuralgia – 1 fl oz |
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The Relief Products Sciatica Therapy Homeopathic, Tablets – 70 count |
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Liddell Homeopathic Back Pain Sciatica – 1 fl oz |
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Magnilife Pain Relief Cream, Leg & Back – 4 oz |
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Boericke & Tafel Sciatic Aide Natural Homeopathic Tablets – 100 count box |
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Be-Active Brace Acupressure Pad Back Pain Sciatica |
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Topical Anti-Inflammatory Pain Relief Cream – 4 oz box |
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MediNatura Nerve Pain Relief 100 Tabs |
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Nurofen Joint Back Pain Relief Max Strength 10% Gel 40G |
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Boiron, Hypericum, Nerve Pain Relief, Meltaway Pellets |
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Topricin Pain Relief Cream – 2 oz |
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Zostrix Natural Pain Relief Cream Original Strength, 2 oz |
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King Bio Dr. King's Natural Medicine Sciatic Nerve Formula, Oral Spray – 2 fl oz |
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- Natural, active ingredients treat symptoms at the source. Gentle.
- Non-habit forming and no drowsiness. Safe.
- No known medication interaction.
- Back Pain, Difficulty Moving Colocynthis HPUS 6x, 12x, 18x
- Neuralgic Pain, then Numbness Gnaphalium polycephalum HPUS 6X, 12x, 18x
- NATURAL INGREDIENTS: Consists of nourishing ingredients such as Aloe and fruit & plant extracts to heal the skin in a natural way.
- Serving Size: Two (2) Tablets.
- Ingredients: (hpus) Arsenicum Album 12x Chamomilla 3x Colocynthis 3x Sulphur 6x.
- Other Ingredients: Lactose Monohydrate Based Tablets, Magnesium Stearate, Microcrystalline Cellulose.
- Brace acupressure pad for back pain and sciatica
- Works on either left or right leg
- Holds firm and comfortably while exercising or at work
- Topricin Anti-Inflammatory Pain Relief Cream is the safest alternative to all prescription and non-prescription OTC pain relieving medication
- For the temporary relief of: Tingling sensation; Shooting pain
- All MediNatura products are homeopathic combination formulas supported by traditional homeopathic principles
- Topical relief for your body aches and pains
- Targeted relief directly at the site of pain
- Soothes and cools
- Hypericum Nerve Pain Relief Bonus Pack 30 C.
- 240 Pellets 05/2025.
- Topricin Anti-Inflammatory Pain Relief Cream is the safest alternative to all prescription and non-prescription OTC pain relieving medication
- Product Description
- For Temporary relief from minor Aches and Pains Safe to use with oral pain relievers
- Product Benefits
- 12 yrs.) 2 pump sprays Infant Dose (Newborn.
- 2 yrs.) 1 pump spray External Use (when appropriate) Simply spray on affected areas 2 to 6 times daily until symptoms improve.
1. NatraBio Sciatica Neuralgia – 1 fl oz
- Natural, active ingredients treat symptoms at the source. Gentle.
- Non-habit forming and no drowsiness. Safe.
- No known medication interaction.
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Amazon.com – Seller | |
Walmart | |
Village Green Apothecary | |
Vitacost.com |
Product Details
Specifications
Details | |
Units in Package | 1 |
Unit Size | 1 fl oz |
Indications | Neuralgic pains. Shooting and throbbing pains. Numbness, heavy back pain. Sciatica, pain in joints and legs. Neuralgic and sciatic pains. Neuralgia. Uses: To relieve, sciatica pain; pain extending into legs; neuralgia; rheumatic pains; backache. |
Directions | Directions: Do not use if printed bottle neck seal is broken or missing. Adults, take 15 drops under the tongue every 20 minutes for 6 doses, then reduce to every 4 hours or as needed. Children 4-12 Years of Age, take one half the adult dosage. |
Ingredients | Active Ingredients: Belladonna 6X. Cimicifuga Racemosa 6X. Gelsemium Sempervirens 6X. Gnaphalium Polycephalum 6X, 12X, 30X. Magnesia Phosphorica 6X. Spigelia Anthelmintica 6X. Inactive Ingredients: Purified Water, USP Alcohol. |
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2. The Relief Products Sciatica Therapy Homeopathic, Tablets – 70 count
- Back Pain, Difficulty Moving Colocynthis HPUS 6x, 12x, 18x
- Neuralgic Pain, then Numbness Gnaphalium polycephalum HPUS 6X, 12x, 18x
- Numbness in legs, buttocks Hypericum perforatum HPUS 6X, 12x, 18x
- Burning, Tingling in legs, toes, feet Kali iodatum HPUS 6X, 12x, 18x
- Lumbar pain, coccyx pain Magnesia phosphorica HPUS 6X, 12x, 18x
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Amazon | |
Walmart | |
Walgreens.com | |
Organic Basic Food |
Product Details
Specifications
Details | |
Directions | Suitable for adults and children ages 2 and over. Children under the age of 2: Consult a physician before use. Dissolve entire tablet under tongue. Do not chew or swallow whole. Take 1 tablet 3 times a day or as directed by a physician. Use up to 6 times a day as needed. Take at least 10 minutes before or at least 10 minutes after eating or drinking. Homeopathic remedies may not be effective for everyone. Individual results may vary. Store at room temperature 15° to 30° C (59° to 86° F). Keep bottle tightly closed. |
Ingredients | Active Ingredients – Purpose: Arnica Montana HPUS 6X, 12X, 18X – Back Aches, Colocynthis HPUS 6X, 12X, 18X – Nerve Discomfort, Gnaphalium Polycephalum HPUS 6X, 12X, 18X – Leg Numbness, Hypericum Perforatum HPUS 6X, 12X, 18X – Tingling Legs, Kali Iodatum HPUS 6X, 12X, 18X – Lumbar Tenderness, Magnesia Phosphorica HPUS 6X, 12X, 18X – Shooting Discomfort, Rhus Tox HPUS 6X, 12X, 18X – Stiffness, Difficulty Moving. “HPUS” Indicates The Active Ingredients Of This Product Are Officially Monographed In The Homeopathic Pharmacopoeia Of The United States. Inactive Ingredients: Advantol 300, Lactose, Magnesium Stearate, Mannitol, Microcrystalline Cellulose. |
Nitrates Free | No |
Shellfish Free | No |
Ready To Heat | No |
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3. Sciaticream Sciatica Pain Cream
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Amazon | |
Botanic Choice |
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4. Liddell Homeopathic Back Pain Sciatica – 1 fl oz
- Size: 1 oz.
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eBay | |
Walmart | |
Organic Basic Food |
Product Details
Specifications
Details | |
Weight | 0.21 lb |
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5. Magnilife Pain Relief Cream, Leg & Back – 4 oz
- NATURAL INGREDIENTS: Consists of nourishing ingredients such as Aloe and fruit & plant extracts to heal the skin in a natural way.
- QUALITY INGREDIENTS: Free from petroleum and mineral oils that can sit on the surface and promote bacteria growth.
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Amazon | |
eBay | |
Walmart – Brownstone brooklyn | |
Rite Aid |
Product Details
Specifications
Details | |
Units in Package | 1 |
Unit Size | 4 oz |
Indications | Uses: For the temporary relief of pain in the lower back, buttocks, and legs. |
Directions | General directions: Generously apply and massage into skin from lower back to feet twice daily. |
Ingredients | Active Ingredients: In Cream Belladonna 3X HPUS, Capsicum Annuum 3X HPUS, Colocynthis 3X HPUS, Gnaphalium Polycephalum 3X HPUS, Rhus Tox 3X HPUS. Purpose: For Aching Back Pain, For Pain While Sitting, For Pain Along Back of Thigh, Pain Reliever, For Pain in the Back and Legs. Inactive Ingredients: Water, Polyacrylamide, C13-14 Isoparaffin, Propylene Glycol, Methylparaben, Propylparaben, Capsicum Annuum Resin, Lavandula Angustifolia (Lavender) Oil, Salvia Officinalis (Sage) Leaf Oil, Benzocaine, Laureth-7, Aloe Barbadendsis Leaf Juice, Magnesium Ascorbyl Phosphate, Tocopheryl Acetate, Folic Acid, Retinyl Palmitate, Calendula Officinalis Flower Extract, Salvia Officinalis (sage) Leaf Extract, Achillea Millefolium Extract, Sambucus Nigra Flower Extract, Foeniculum Vulgare (Fennel) Seed Extract, Citrus Aurantium Dulcis (Orange) Flower Extract, Rosa Canina Flower Extract, Geranium Maculatum Extract |
6. Back Pain Sciatica 1 oz ea by Liddell Laboratories, Pack of 2
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Amazon | |
Walmart – Lowest Seller LLC |
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7. Boericke & Tafel Sciatic Aide Natural Homeopathic Tablets – 100 count box
- Serving Size: Two (2) Tablets.
- Ingredients: (hpus) Arsenicum Album 12x Chamomilla 3x Colocynthis 3x Sulphur 6x.
- Other Ingredients: Lactose Monohydrate Based Tablets, Magnesium Stearate, Microcrystalline Cellulose.
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Amazon | |
Walmart | |
Organic Basic Food | |
Swanson Health Products |
Product Details
Specifications
Details | |
Units in Package | 100 |
Indications | For temporary relief of the minor aches & pain associated with sciatica. |
Directions | Sublingual medication. Place tablets under tongue at least 15 minutes before or half hour after eating, brushing teeth, or drinking anything except water. Adults & Children 12 Years of Age & Older: 2 tablets every two hours until relieved. Children Under 12: Consult a doctor. Store at room temperature out of direct sunlight. |
Ingredients | Active Ingredients (HPUS): Arsenicum Album 12X, Chamomilla 3X, Colocynthis 3X, Sulphur 6X. Inactive Ingredients: Lactose Monohydrate Based Tablets, Magnesium Stearate, Microcrystalline Cellulose. |
Warnings | For your protection, this bottle is sealed with a perforated ring around the cap. Do not use if seal is broken. Do not take this product for pain for more than 10 days unless directed by a doctor. If pain persists, gets worse, is accompanied by fever, is prominent while lying down, or if new symptoms occur, or redness or swelling is present, consult a doctor because these could be signs of a serious condition. As with any drug, if you are pregnant or nursing a baby, seek the advice of a health professional before using this product. Keep out of the reach of children. |
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8. MagniLife Leg & Back Pain Relief Cream
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Amazon | |
Walmart – Brownstone brooklyn | |
Easy Comforts | |
Dream Products |
Product Details
Specifications
Details | |
Assembled Product Weight | 0.3 lb |
Assembled Product Dimensions (L x W x H) | 3.00 x 3.00 x 3.00 Inches |
9. Topricin Pain Relief Therapy Cream 8 oz Fast Acting Pain Relieving Rub
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eBay | |
Newegg.com – Famous Microgreens |
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10. Forces of Nature Back Pain, Roll On, Arnica Montana – 0.14 oz
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Amazon | |
Walmart – Forces of Nature, Inc. | |
Forces of Nature |
Product Details
Specifications
Details | |
Units in Package | 1 |
Unit Size | 0.14 oz |
Indications | Uses: Relieves back pain and soreness due to overuse, strain, spasm, or trauma. |
Directions | Directions: Shake well before use. Simply roll on the problem area. Gently rub into the skin. Apply as needed. |
Ingredients | Active Ingredients: Arnica Montana (USDA Certified Organic) 30C, Aesculus Hippocastanum (USDA Certified Organic) 6C, Hypericum Perforatum (USDA Certified Organic) 12C, Ruta Graveolens (USDA Certified Organic) 30C, Natrum Muriaticum (USDA Certified Organic) 30C. Purposes: Relief for Muscle/Tendon Pain, Relief for Constant Backache, Relief for Back/Spinal Pain, Relief for Pain in the Nape and Loins, Relief for Lower Backache. Inactive Ingredients: Sesame Oil (USDA Certified Organic), Lavandin Oil (USDA Certified Organic), Pine Oil (USDA Certified Organic), German Chamomile Oil (USDA Certified Organic). |
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11. Be-Active Brace Acupressure Pad Back Pain Sciatica
- Brace acupressure pad for back pain and sciatica
- Works on either left or right leg
- Holds firm and comfortably while exercising or at work
- Discreet and easily hidden under your clothing
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Amazon | |
Ready Gears |
Product Details
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12. BraceAbility Lumbar Back Brace | Chronic Pain Relief from Sciatica and Pinched Nerve – L
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Amazon | |
BraceAbility | |
Discount Bandit – Health & Beauty Mart |
Product Details
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13. Topical Anti-Inflammatory Pain Relief Cream – 4 oz box
- Topricin Anti-Inflammatory Pain Relief Cream is the safest alternative to all prescription and non-prescription OTC pain relieving medication
- It heals the damage that is causing the pain
- Safe and effective for the elderly, children, pregnant women
- Suitable for all skin types
- Great relief for damaged muscle, tendon, ligament and nerve tissue
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Walgreens.com |
Product Details
Specifications
Details | |
Units in Package | 1 |
Unit Size | 4 oz |
Indications | Uses: Rapid soothing relief of pain, stiffness, tingling or burning nerve pain associated with: arthritis and other joint pain and discomfort; fibromyalgia; carpal tunnel syndrome and other types of nerve pain; pains and muscle cramps of the back, neck, shoulder, legs, hands and feet; sports injuries (muscle pulls & soreness, impact injury, sprains, dislocations); repetitive motion injuries, such as bursitis, tendonitis and sciatica; first aid for simple trauma (bruises, minor burns, cuts, scrapes and strains). |
Directions | Directions: Directions for Best Results: Generously apply 3-4 times daily or more often if needed, 3 inches on and around affected skin. Massage in until absorbed, re-apply before bedtime and in the morning. Use before and after sports work outs and competitions. Apply immediately for acute trauma injuries (sprain, strain, bruise, and impact injuries). For directions specific to injury/trauma, see insert on the inside of this box. |
Ingredients | Active Ingredients: Aesculus Hippocastanum 6X, Arnica Montana 6X, Belladonna 6X, Crotalus Horridus 8X, Echinacea 6X, Graphites 6X, Heloderma 8X, Lachesis Mutus 8X, Naja Tripudians 8X, Rhus Toxicodendron 6X, Ruta Graveolens 6X. Purpose: Relieves Pain in the Lower Back, Hip and Spine, Treats Pain of Impact, Falling Injuries and Contusion to Muscles and Joints, Treat Muscle Spasms, Night Leg Cramps, Relief of Impact Injuries & Deep Muscle Bruising, Relieves Sharp Stitching Pain in Joints & Muscles, Relieves Skin Conditions, Relief of Burning Pain in the Hands and Feet, Relief of Sciatic Pain and Carpal Tunnel, Relieves Nerve Injury Pain, Pain Relief for Muscle Cramping, Joint and Post-Surgical Pain, Relief of Injuries to the Knee, Shin and Elbow. Inactive Ingredients: Captex 300 (from Coconut Fatty Acids), Carbopol Ultrez 10 (from Sucrose), Cetyl Alcohol (from Coconut Oil), Spectrastat G2 (Derived from Coconut), Glycerine (Vegetable Based), Hydrokote (Palm Kernel Oil with Lecithin), Isopropyl Myristate Emollient (from Palm Seeds), Lipomulse (from Coconut Fatty Acids), Purified Water, Sodium Hydroxide, Steareth-21 (from Stearic Acid Cocoa Butter. |
Warnings | Warnings: For external use only. Ask a doctor before using if you are pregnant or nursing. Other warnings: Do not apply in eyes. Keep all medicines out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Use only as directed. See doctor if pain persists for more than 3 days or worsens, if new symptoms occur, or if redness or swelling are present because these could be signs of a more serious condition. Before considering any self help regimen always consult your doctor, especially if you are taking a prescription medication. |
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14. MediNatura Nerve Pain Relief 100 Tabs
- For the temporary relief of: Tingling sensation; Shooting pain
- All MediNatura products are homeopathic combination formulas supported by traditional homeopathic principles
- These statements have not been reviewed by the Food and Drug Administration
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Amazon | |
Walmart – Swanson Health Products | |
Swanson Health Products | |
PureFormulas.com |
Product Details
Specifications
Details | |
Product Dimensions | 1.7 x 1.7 x 3.06 inches |
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15. Nurofen Joint Back Pain Relief Max Strength 10% Gel 40G
- Topical relief for your body aches and pains
- Targeted relief directly at the site of pain
- Soothes and cools
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Amazon | |
Britishonlinesupermarket.com |
Product Details
Specifications
Details | |
Package Dimensions | 7.68 x 2.32 x 2.28 inches; 3.21 Ounces |
Package Dimensions | 7.68 x 2.32 x 2.28 inches; 3.21 Ounces |
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16. Boiron, Hypericum, Nerve Pain Relief, Meltaway Pellets
- Hypericum Nerve Pain Relief Bonus Pack 30 C.
- 240 Pellets 05/2025.
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eBay – iherb | |
Walmart | |
Boiron USA |
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Details | |
Assembled Product Weight | 0.0850 oz |
Inactive Ingredients | Lactose Sucrose |
Active Ingredients | Hypericum perforatum 30C HPUS |
Written by a | Boiron |
17. Topricin Pain Relief Cream – 2 oz
- Topricin Anti-Inflammatory Pain Relief Cream is the safest alternative to all prescription and non-prescription OTC pain relieving medication
- It heals the damage that is causing the pain
- Safe and effective for the elderly, children, pregnant women
- Suitable for all skin types
- Great relief for damaged muscle, tendon, ligament and nerve tissue
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Amazon | |
eBay – bluemedical | |
Smallflower.com | |
ZeZeBuy |
Product Details
Specifications
Details | |
Units in Package | 1 |
Unit Size | 2 oz |
Indications | Uses: Rapid, soothing relief of pain, stiffness, tingling or burning nerve pain associated with: arthritis and other joint pain and discomfort; fibromyalgia; carpal tunnel syndrome and other types of nerve pain; pains and muscle cramps of the back, neck, shoulder, legs, hands and feet; sports injuries (muscle pulls & soreness, impact injury, sprains, dislocations); repetitive motion injuries, such as bursitis, tendonitis and sciatica; first aid for simple trauma (bruises, minor burns, cuts, scrapes and strains). |
Directions | Directions: Directions for Best Results: Generously apply 3-4 times daily or more often if needed, 3 inches on and around the affected area. Massage in until absorbed, re-apply before bedtime and in the morning. Use before and after sports work outs and competitions. Apply immediately for acute trauma injuries (sprain, strain, bruise, and impact injuries). |
Ingredients | Active Ingredients: Aesculus Hippocastanum 6X, Arnica Montana 6X, Belladonna 6X, Crotalus Horridus 8X, Echinacea 6X, Graphites 6X, Heloderma 8X, Lachesis Mutus 8X, Naja Tripudians 8X, Rhus Toxicodendron 6X, Ruta Graveolens 6X. Purpose: Relieves Pain the Lower Back, Hip and Spine, Treats Pain of Impact, Falling Injuries and Contusion to Muscles and Joints, Treats Muscle Spasms, Night Leg Cramps, Relief of Impact Injuries and Deep Muscle Bruising, Relieves Sharp Stitching Pain in Joints and Muscles, Relieves Skin Conditions, Relief of Burning Pain in Joints and Muscles, Relieves Skin Conditions, Relief of Burning Pain in the Hands and Feet, Relief of Sciatic Pain and Carpal Tunnel, Relieves Nerve Injury Pain, Pain Relief for Muscle Cramping, Joint and Post-Surgical Pain, Relief of Injuries to the Knee, Shin and Elbow. Inactive Ingredients: Captex 300 (from Coconut Fatty Acids), Carbopol Ultrez 10 (from Sucrose), Cetyl Alcohol (from Coconut Oil), Spectrastat G2 (Derived from Coconut), Glycerine (Vegetable-Based), Hydrokote (Palm Kernel Oil with Lecithin), Isopropyl Myristate Emollient (from Palm Seeds), Lipomulse (from Coconut Fatty Acids), Purified Water, Sodium Hydroxide, Steareth-21 (from Stearic Acid Cocoa Butter). |
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18. Zostrix Natural Pain Relief Cream Original Strength, 2 oz
- Product Description
- For Temporary relief from minor Aches and Pains Safe to use with oral pain relievers
- Product Benefits
- Ingredients
- Special Note
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Amazon | |
Lorena Pharmacy |
Product Details
Specifications
Details | |
Container Type | Tube |
Active Ingredients | Capsaicin |
Dosage Form | Cream |
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19. King Bio Dr. King’s Natural Medicine Sciatic Nerve Formula, Oral Spray – 2 fl oz
- 12 yrs.) 2 pump sprays Infant Dose (Newborn.
- 2 yrs.) 1 pump spray External Use (when appropriate) Simply spray on affected areas 2 to 6 times daily until symptoms improve.
- Or as directed by your healthcare professional.
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LuckyVitamin |
Product Details
Specifications
Details | |
Units in Package | 1 |
Unit Size | 2 fl oz |
Indications | Uses: For temporary relief of symptoms: leg, back, hip and joint discomfort; numbness and tingling; tightness and stiffness; muscular fatigue. |
Directions | Directions: Keep carton for complete drug facts and product information. Initially, depress pump until primed. Spray one dose directly into mouth. Use additionally as needed, up to 6 times per day. Adults (12 and Up): 3 sprays 3 times per day. |
Ingredients | Active Ingredients: Equal Volumes in Each Ingredient in 10X, 30X, and LM1 Potencies: Aesculus Hippocastanum, Ammonium Muriaticum, Arsenicum Album, Belladonna, Capsicum Annuum, Causticum, Colchicum Autumnale, Colocynthis, Gnaphalium Polycephalum, Ignatia Amara, Magnesia Phosphorica, Rhus Toxicodendron. Purpose: Discomfort in Back, Legs, Arms, HPUS; Discomfort, Tightness in Hips, HPUS; Uneasiness, Fatigue in Legs, HPUS; Discomfort in Limbs, HPUS; Stiffness in Legs, HPUS; Discomfort with Motion, HPUS; Numbness, Tingling in Limbs, HPUS; Discomfort from Hip to Knee, HPUS; Discomfort in Limbs, HPUS; Weakness in Back and Lower Limbs, HPUS; Muscular Fatigue, HPUS; Discomfort in Legs, Hips, Joints, HPUS. Inactive Ingredients: Bio-Energetically Enhanced Pure Water, Citric Acid, and Potassium Sorbate. |
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20. Voltarol Back & Muscle Pain Relief 100 G
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Pharma Oasis |
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Conclusion
The conclusion of pain killer for sciatica is that it can be an effective way to manage pain and improve quality of life. However, it is important to work with a healthcare professional to determine the best course of treatment.